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The MD Anderson algorithm intentionally adopts a stepped-care approach for VEGFi-related hypertension to reflect the unique clinical context of oncology patients, in whom VEGFi regimens may involve on-off treatment cycles and may also change rapidly based on therapeutic response or toxicity

Zalutsky RA, Nicoll RA (1990)

Because of this, it can help reduce the appearance of uneven pigmentation and dullness

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