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Strikingly, GPx4 mRNA levels remained unchanged under ethanol treatment, while GPx4 protein expression was upregulated in both ethanol-exposed AML12 cells and primary hepatic cells (PHC) (Fig

AHK-Cu (Ala-His-Lys-Cu) is a related copper tripeptide found in human plasma that shares the His-Lys copper-binding motif but substitutes alanine for glycine at the N-terminal position, resulting in a slightly different copper coordination geometry and a distinct (though overlapping) gene expression modulation profile

Treatment with GLP-1inactive MK-801 produced no additional weight loss efficacy relative to GLP-1 monotherapy (Fig

We also did not measure brain levels of glutamate or inhibitory GABA, which are neuro-transmitters known to be impacted by the ketogenic diet in various animal models

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