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20, 55 As p53 abnormalities are associated with poor prognosis in MM, 2, 49 the ability of BSO+L-PAM to induce cell death by circumventing p53 loss-of-function may provide a viable therapeutic option for patients with del17p13 MM
The siRNA-NP targeting diverse molecular mechanisms implicated in Alzheimer's disease, to downregulate genes such as bridging integrator 1 (BIN1), sortilin-related receptor 1 (SORL1), and clusterin (CLU) has proven useful in various animal models (105)
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doi: 10.1111/j.1349-7006.2012.02216.x
