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This patient's primary issue is a lack of central dopamine causing motor freezing, and inhibiting its conversion to norepinephrine would not alleviate these extrapyramidal symptoms

The mechanism by which glutamate is increased in neurodegenerative diseases is unknown

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Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model

Cardiac output is the total volume of blood pumped from the ventricle per unit of time, which is calculated by multiplying the stroke volume with the heart rate