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From a market perspective, the demand for antifungal drugs continues to rise: The market is expected to expand at a compound annual growth rate (CAGR) of 2.81% from 2020 to 2033, with a size of 14.09 billion US dollars in 2024, expected to rise to 14.48 billion US dollars in 2025, and reach 18.08 billion US dollars by 2033 ( Figure 1 ) (Insights, 2025).However, the development and application of antifungal drugs face numerous challenges (Fisher et al., 2018

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Up to respectively 70 and 40 M, AQ or DEAQ did not significantly activate any of the tested stress response pathways, which is consistent with the limited onset of cytotoxicity by these compounds ( Figure 2 )

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PMID: 33041520