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A conceptual framework of a 4-signal model of T cell activation together with an ever improving map of the differentiation trajectories of CD8 + T cells should continue to provide a foundation for understanding and improving cancer immunity

Elevated levels of lipid peroxidation markers (e.g., MDA, 4-HNE) in the substant nigra of PD patients, co-localized with necrotic neurons, directly implicate oxidative damage in necrosis