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Studies have shown that inhibiting HDAC6 can reduce NF-B activity, thereby diminishing inflammatory responses in various cell types

One compound that has garnered significant attention in both functional medicine and recent clinical trials is N-Acetyl-L-Cysteine, commonly known as NAC

E., Characteristics and Outcomes of Patients Receiving Physical Therapy for Low Back Pain With a Nociplastic Pain Presentation: A Secondary Analysis, Pain Research and Management 2023 (2023): 110

It is typically prescribed for short-term use only (12 weeks), though some physicians prescribe it longer

Nonetheless, these two routes are not mutually exclusive