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Further, 4-hyroxynonenal (HNE), a major lipid peroxidation product, induces Nrf2 signalling and the expression of GSH-synthesizing enzymes, thereby increasing the level of GSH in the cells [29]

Cytochrom P 450 Polymorphismus fr die Varianten CYP 1A1, CYP1A2, CYP2A6, CYP2D6, CYP2E1, CYP2C9, CYP2C19 und CYP 2E1 In der genetischen Analyse verschiedener Cytochrom P450-Varianten kann festgestellt werden, ob der Patient eine eingeschrnkte Entgiftungskapazitt der Phase I bereits in seinem Erbgut trgt