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An early analysis of the results of 12 randomized controlled trials showed that folic acid supplementation (0.5-5 mg/day) had the greatest lowering effect on blood homocysteine concentrations (25% decrease)

Minor and temporary irritation of the veins with regular use

[1] In moderate deficiencies, feeling tired, feeling faint, mouth ulcers, rapid breathing, upset stomach, pallor, hair loss, decreased ability to think and joint pain and the beginning of neurological symptoms, including abnormal sensations such as, numbness and tingling, and tinnitus may occur

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It is naturally found in a variety of animal foods and is available as a dietary supplement or through vitamin injections