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Therapeutics like GLP-1R agonists (e.g., semaglutide, liraglutide), dual agonists like tirzepatide, and triple agonists like retatrutide have shown significant promise in treating these metabolic disorders

At the hypothalamus level, food intake reduction occurs either through direct action at GcgR within the arcuate nucleus or via GcgR-expressing afferent vagal nerves from the liver [14]

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Although mild relapses may not require treatment (90), there is a consensus that moderate to severe disabling relapses should be treated using systemic steroids (preferably corticosteroids)

IM methods provide slower, more stable uptake