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Lack of physical activity (sedentary lifestyle), poor blood circulation , dehydration (drinking insufficient amount of water), stress, irritability, anxiety , and depression are also associated with the development of RLS

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(1) Stimulate chondrocytes to synthesize Col-II and proteoglycans, while inhibiting the activities of MMP-13 and ADAMTS-5, and reducing matrix degradation

Graves disease is an autoimmune disorder, in which thyroid-stimulating antibodies activate the thyroid-stimulating hormone (TSH) receptors, triggering increased thyroid hormone synthesis