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650 Ferroptosis in traumatic brain injury Traumatic brain injury (TBI) is a significant global cause of disability and mortality, 651 with complex underlying mechanisms such as excitatory neurotoxicity, apoptosis, oxidative stress, inflammatory response, and intracellular calcium overload

This process is mediated by a specific cargo receptor, nuclear receptor coactivator 4, which recognizes and binds to ferritin, targeting it for lysosomal degradation (24)

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Ren J, Samson WK, Sowers JR