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Patients with a history of severe gastrointestinal disease, particularly those with inflammatory bowel disease, severe gastroesophageal reflux disease, or history of pancreatitis, require careful evaluation before considering this therapy
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The absence of mucin, a highly glycosylated polymeric protein in the mucous layer, makes an animal vulnerable to intestinal inflammation, which leads to the development of spontaneous colitis and confers a predisposition to the development of colorectal cancers (Fig
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