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( GAP1 expression from its native promoter would not serve as a good control here because pGAP1 is repressed by the ammonium sulphate N-source and so D-HIS would not be taken up by the cells)

J.SikiricP.KimD

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Clinical research should further validate the potential application of HIF-2 in personalized treatment, alongside ferroptosis markers like GPX4, to precisely regulate the survival environment of chondrocytes, advancing and refining OA treatment