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No dosage adjustment is recommended for renal or hepatic impairment, though patients should be monitored for dehydration-related acute kidney injury during significant gastrointestinal adverse effects

J Clin Endocrinol Metab (2001) 86(4):171623.10.1210/jcem.86.4.7403 48 GentJvan KerkhofPRozaMBuGStrousGJ
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The treated cells showed markedly reduced lipogenesis

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