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When these systems are under-resourced or overwhelmed, oxidative pressure can amplify inflammation and cellular dysfunction (Jewell DE, 2024)

Longitudinal studies show that gastrointestinal symptoms such as constipation may precede motor manifestations by up to two decades, supporting the involvement of gutbrain axis [120]

Kreppel LK, Blomberg MA, Hart GW

However, some experiments have shown that a decreased ALT/AST ratio is not only linked to the accumulation of A protein and cerebral atrophy but also related to impaired glucose metabolism in the frontal, parietal, and temporal lobes [2]

Calmodulin promotes dimerization of the oxygenase domain of human endothelial nitric-oxide synthase