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Glutamine is imported into cells by distinct carriers from the families of Slc1, Slc6, Slc7, and Slc38 transporters, serving as an essential carbon and nitrogen source for many of these cells, including tumor cells (e.g., pancreatic ductal adenocarcinoma [170]), breast cancer cells [171], and immune cells

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those potentially deficient in the micronutrient (holo-TC 271 nmol/L with holo-TC being very low or low (Herrmann and Obeid, Berg and Shaw presented a cascade-testing algorithm that stratified patients first by total serum vitamin B 12 levels and second by MMA levels, using cutoffs of 118 pmol/L and 0.80 mol/L, respectively (Berg and Shaw, 12 therapy in patients

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doi: 10.1016/j.bbagen.2008.06.003