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doi:10.1016/S0021-9258(18)65950-2
They are unapproved drugs
While nintedanib was shown to reduce the rate of decline of FVC, it had no effect on extra-pulmonary manifestations of systemic sclerosis such as skin changes measured by the Rodnan skin score
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Children with severe asthma had increased GSSG, lipid peroxidation, byproducts of DNA oxidation, and inflammation in the ELF
