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Additionally, impaired calcium homeostasis, particularly in neurons, results in excitotoxicity and apoptosis, thereby contributing to neurodegeneration [18,19]

This triad, along with endothelial dysfunction, which can also be induced by aberrant insulin signaling, contribute to atherosclerotic plaque formation

Trimethylamine NOxide Supplementation Abolishes the Cardioprotective Effects of Voluntary Exercise in Mice Fed a Western Diet. Frontiers in Physiology 8: 944

Tanaka et al., 1992

In contrast, when NKA activity was isolated from that of inward Ca 2+ an Na + currents, as well NCX1 and the inward rectifying K + current, Wu and Corr (1995) found that LCAC application only modestly depolarises the RMP when compared to ouabain (13 vs