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Elevated cytosolic NADH/NAD + and its resulting reductive stress were observed in early diabetic animals owing to increased oxidation of substrates ( e.g

[DOI] [PubMed] 459.Tomat AL, Inserra F, Veiras L, Vallone MC, Balaszczuk AM, Costa MA, et al

In cholesterol metabolism, H 2 O 2 /O/OH/LOOH inhibit cholesterol synthesis by oxidatively modifying HMG-CoA reductase [195, 196]
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nature 596 (7873), 583589