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He Y, Wang W, Yang T, Thomas ER, Dai R, Li X
Trazodone, for example, metabolizes to mCPP, a BZP analogue that is significantly more harmful than straight-up BZP
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This rapid clearance may help prevent the toxic accumulation of mediators in the bloodstream, significantly reducing the severity and duration of systemic MCAS flares, such as flushing, gastrointestinal distress, and neurological inflammation
1-carboxyphenyalanine is reported to be associated with poor response to metformin (Naja et al., 2023) and with lower microbiome diversity (Wilmanski et al., 2019), and previously shown to be most discriminating metabolite of insulin resistance (ahin et al., 2022)
