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In these cases, I explain the limitations clearly and discuss whether another approach, a different goal, or waiting until conditions are more favorable may be more appropriate

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Thus, given the potential antagonistic effects of MDMA on mesolimbic DA release, it is not surprising that MDMA coadministration has also been shown to attenuate the reinforcing effects of both cocaine (Diller et al., 2007) and METH (Clemens et al., 2006) in rats