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In contrast, the EEBC-100 and EEBC-200 groups showed a significant increase in the percentage of spontaneous alternations compared with that in the SCO group (Fig
Yap, yes-associated protein)
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However, monotherapy with the Hh pathway inhibitor vismodegib did not show any significant antitumor activity in patients with ovarian cancer in a phase II clinical trial (NCT00739661) [189]
