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It has decades of prescribing history behind it

While topical application has minimal systemic absorption, the precautionary principle suggests avoiding use during pregnancy unless a healthcare provider approves

Therefore, LL-37 gets tightly attached to bacteria, and the peptide inserts itself into the lipid bilayer and disrupts its structure, causing the membrane to leak essential ions and metabolites, leading to rapid cell death

Lastly, as previously discussed, BPC-157 robustly stimulates the NO system, which, at high levels, inhibits heme insertion into hemoglobin and alters the activity of heme thiolate enzymes and CYP enzymes [54, 76, 77]

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