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Common ingredients in pre-workouts include: L-Citrulline Small studies using lower doses of L-citrulline malate have shown some improvements in cycling performance and muscle soreness, though some larger-scale meta-analyses of aerobic performance have revealed mixed results, even with higher doses.35 36 Other large reviews have been more positive, especially at 8g/day and above.45 The trend in the literature seems to indicate that higher doses would be more effective, though many pre-workout supplements offer 6g or less

Excessive alcohol consumption is considered a risk factor for the development of cancer in the upper gastrointestinal tract, because of exposure to acetaldehyde, which is carcinogenic to humans

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Chae CU, Albert CM, Moorthy MV, Lee IM, Buring JE

The NLS is composed of two clusters of basic amino acids separated by ten residues (617-RKCYEAGMTLGARKLKK-634), a motif that is highly conserved with that of the GR, MR and PR steroid hormone receptors