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b Hanson et al., c Dooley et al., d Lohman and Remington, e Schwarzlnder et al., f Dihydrolipoic acid (DHLA, reduced form), Lipoic acid (LA, oxidized form)

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To effectively intervene in oxidative stress damage within hypoxia-related pathological processes, the core strategy targeting the HIF pathway focuses on regulating the generation and homeostasis of pathological ROS, rather than solely addressing hypoxia adaptation itself

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The mechanism can be explained by the following two aspects: First, receptors for 25[OH]D3 are present in nerve cells and its deficiency can cause olfactory nerve dysfunction, resulting in olfactory decline (154)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 186.Sambandamurthy VK, Derrick SC, Hsu T, Chen B, Larsen MH, Jalapathy KV, Chen M, Kim J, Porcelli SA, Chan J, Morris SL, Jacobs WR

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