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b Hanson et al., c Dooley et al., d Lohman and Remington, e Schwarzlnder et al., f Dihydrolipoic acid (DHLA, reduced form), Lipoic acid (LA, oxidized form)

To effectively intervene in oxidative stress damage within hypoxia-related pathological processes, the core strategy targeting the HIF pathway focuses on regulating the generation and homeostasis of pathological ROS, rather than solely addressing hypoxia adaptation itself

The mechanism can be explained by the following two aspects: First, receptors for 25[OH]D3 are present in nerve cells and its deficiency can cause olfactory nerve dysfunction, resulting in olfactory decline (154)

[DOI] [PMC free article] [PubMed] [Google Scholar] 186.Sambandamurthy VK, Derrick SC, Hsu T, Chen B, Larsen MH, Jalapathy KV, Chen M, Kim J, Porcelli SA, Chan J, Morris SL, Jacobs WR

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