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10.1016/j.cryobiol.2020.08.007 56

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FDAs 2023 Category 2 placement cited significant immunogenicity risk for some routes of administration, plus impurity and API characterization concerns

Specialized pro-resolving lipid mediators (SPMs), including resolvins, protectins, maresins, and lipoxins, are endogenous lipids derived from omega-3 fatty acids like eicosapentaenoic acid and docosahexaenoic acid, orchestrating the resolution of inflammation (Julliard et al., 2022

Importantly, both NOX1- and NOX2-produced ROS are required for the activation and differentiation of monocytes into proinflammatory M1 and anti-inflammatory M2 macrophages 77