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DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

Chang M, Wang M, Wang M, Shu M, Ding B, Li C, et al

Quercetin as a promising intervention for rat osteoarthritis by decreasing M1-polarized macrophages via blocking the TRPV1-mediated P2X7/NLRP3 signaling pathway

This Cdc48/p97Ufd1Npl4 ATPase complex unfolds protein substrates carrying a Lys48-linked polyubiquitin chain and extracts them from membranes or macromolecules, prior to their degradation by the proteasome 2,57

In cases of intensive repair protocols where accelerated healing is the objective over a short period higher concentrations may be used, but these should be monitored closely for potential side effects