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The increased population of CD8 + T cells in adipose tissue is hypothesized to promote and maintain the pro-inflammatory M1 phenotype of ATMs with age [94, 102]
Additionally, HGF/c-Met signaling regulates the NADPH oxidase system, initiating an Nrf2-mediated protective response

10.1385/JMN:19:3:267 75 Laveriano-SantosE
