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Subcutaneous administration minimizes these effects by reducing required dose and avoiding first-pass gut metabolism [8]
Roflumilast attenuates doxorubicin-induced cardiotoxicity by targeting inflammation and cellular senescence in cardiomyocytes mediated by SIRT1
In conflict with these findings, Hao et al
2021;10:e00579-21
This is because albumin accounts for ~7080% of the total osmotic pressure in plasma and is the main regulator of fluid distribution in the body cavity (40)
