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Periodic boundary conditions were used with a cutoff of 10 for non-bonded interactions and the Particle Mesh Ewald method for long-range electrostatics

10 mg protocol (8 weeks, 3 vials): 9 mL 1 10 mL bottle 5 mg protocol (8 weeks, 6 vials): 18 mL 2 10 mL bottles 10 mg protocol (12 weeks, 5 vials): 15 mL 2 10 mL bottles Alcohol Swabs One for the vial stopper + one for the injection site each day

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