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Astrocytes can promote seizures and inflammatory responses in mice with temporal lobe epilepsy by activating the NF-B signaling pathway [35], while ALB can reduce ROS by inhibiting the activation of NF-B pathway [36]

Clinically, IGF-1 is used to treat patients who suffer from muscle wasting due to conditions like HIV, or patients with hormonal deficiency [1]

Another form of affinity matrix that has been used widely is the immobilized GSH-agarose matrix [84]

Numerous studies have demonstrated that patients with compromised liver function due to alcohol abuse have significant reduction of Glutathione in the liver

Knockdown of NLRP3 or caspase-1 reduced neuronal death and reversed cognitive impairments [147], whereas PARP-1 -/- mice were observed to prevent synaptic damage, cognitive dysfunction, and microglial activation in an AD mouse model referring to the significant role of pyroptosis and parthanathos in the pathogenesis of AD [148, 149]