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Pankiv S, Clausen TH, Lamark T, Brech A, Bruun J-A, Outzen H et al

Experiments often involve rodent or cell-based systems and measure metabolic flux, markers in adipose and muscle tissues, and transcription patterns affected by NNMT activity

Conversely, a few studies reported high levels of vitamin B12 in the blood of patients with a worse COVID-19 outcome 48,49 potentially due to cytolysis leading to the release of intracellular B12 into the plasma and disrupted B12 clearance by the liver, which is often affected in these patients 50

Researchers are investigating whether 5-Amino-1MQ can leverage these properties to positively influence metabolism

Biochimica et Biophysica Acta 1822, 822829