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Excessive removal of intracellular reactive oxygen species, to nonphysiological levels (or antioxidative stress), could be a cause of in vitro toxicity induced by these drugs

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Interestingly, inflammation-induced increase in zinc levels regulates inflammatory response inhibiting further IL-6 release and interfering with NF-kB activation (262) ( Figure 3A a, c)

It should be added that PEDF/neurotropic factors are unlikely to be exclusive targets of excess extracellular zinc in glaucoma, which can affect a number of proteins (Table 2)

More specifically, literature 446,449 indicates that the termination was due to the lack of help in cognition and the emergence of side effects such as nightmares, weight loss, rash, and liver damage