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Recording with a camera attached to a VMS-004 Discovery Deluxe USB microscope (Veho, Claymont, DE, USA) was performed until the end of the experiment and assessed at 60 min (25 mmHg), 30 min (30 mm Hg), or 25 min (40 mm Hg) reperfusion time

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Abbreviations used: A amyloid beta AD Alzheimer disease Akt protein kinase B AP-1 activator protein 1 ApoE / apolipoprotein E-deficient mice ARE antioxidant response element ASK1 apoptosis signal-regulating kinase 1 BH 4 tetrahydrobiopterin CAD coronary artery disease CBS +/ mice heterozygous deficient for cystathionine beta-synthase ERK1/2 extracellular signal-regulated kinase 1/2 eNOS endothelial nitric oxide synthase FAK focal adhesion kinase GPx1 glutathione peroxidase 1 GPx1 +/+ GPx1 wild type mice GPx1 / homozygous GPx1 knockout mice GPx1 +/ heterozygous GPx1 knockout mice GSH reduced glutathione GSSG oxidized glutathione ICAM1 intercellular adhesion molecule 1 I/R ischemia reperfusion JNK c-Jun N-terminal kinase Keap1 Kelch-like ECH-associated protein 1 MAPK mitogen-activated protein kinase MCAO middle cerebral artery occlusion mcm 5 U 5-methoxy-carbonylmethyluridine mcm 5 Um 5-methoxy-carbonylmethyl-2- O -methyluridine MCSF macrophage colony stimulating factor NFB nuclear factor kappa B NMDA N-methyl-D-aspartate NOX1 NADPH oxidase 1 NOX2 NADPH oxidase 2 NOX4 NADPH oxidase 4 Nrf2 nuclear factor erythroid 2-related factor 2 OTC L-2-oxothiazolidine-4-carboxylic acid oxLDL oxidized low-density lipoproteins PGC1 peroxisome proliferator-activated receptor--coactivator 1 PI3K phosphatidylinositol 3-kinase PKC II protein kinase C beta II ROS reactive oxygen species ROS1 ROS proto-oncogene 1, receptor tyrosine kinase SBP2 SECIS binding protein 2 Sec selenocysteine SECIS selenocysteine incorporation sequence SHP-2 SH2 domain-containing protein tyrosine phosphatase-2 TNF tumor necrosis factor alpha TRAF tumor necrosis factor receptor-associated factor VCAM1 vascular cell adhesion molecule 1 Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

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