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Similar to IgG4s, MuSK IgG1-3s are indeed able to disperse in vitro agrin-induced AChR clusters in C2C12 myotubes, even though they do not inhibit the LRP4-MuSK interaction (Koneczny et al., in vitro model in which AChR clusters were constitutively induced in the myotubes by the overexpression of DOK7 rather than by the normal stimulation with agrin

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6 1996 Strategy for the Design of Non-Peptidic Inhibitors Successful Design of a Non-Peptidic Inhibitor articles Structure Based Drug Design: the Discovery of Novel Non-Peptide Orally Active Inhibitors of Human Renin Rahuel J, Rasetti V, Maibaum J, Rueger H, Goeschke R, Cohen NC, Stutz S, Cumin F, Fuhrer W, Wood JM and Gruetter M Chemistry & Biology 7 2000 Structure-based drug design and the discovery of aliskiren (Tekturna): perseverance and creativity to overcome a R and D pipeline challenge Nissim Claude Cohen Chem Biol Drug Des 70(6) 2007 10.1111/j.1747-0285.2007.00599.x Optimization of the Tetrahydroquinoline Inhibitor articles Structure-based drug design and the discovery of aliskiren (Tekturna): perseverance and creativity to overcome a R and D pipeline challenge Nissim Claude Cohen Chem Biol Drug Des 70(6) 2007 10.1111/j.1747-0285.2007.00599.x A Third Generation of Renin Inhibitors Alignment of the Non-Peptide Inhibitors in 3D Case Study-5 : Inhibitors of HLE Inhibition of Human Leukocyte Elastase Problem of Peptide-Based ICI-200,880 articles Biologic Characterization of ICI 200,880 and ICI 200,355, Novel Inhibitors of Human Neutrophil Elastase Williams JC, Falcone RC, Knee C, Stein RL, Strimpler AM, Reaves B, Giles RE and Krell RD Am