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The use of A42H13L (TABLE 1), in which one of the adjacent His residues was replaced by Leu, a substitution that would preclude any bidentate Cu 2+ ligand binding, led to results consistent with the notion that bidentate Cu 2+ ligand binding of these His residues was not essential for the oxidative damage and cellular toxicity of the native peptide (115)

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Neuroprotective and Mood-Enhancing Effects : Studies suggest that Melanotan II exerts neuroprotective and mood-modulating actions through the melanocortin systems influence on dopamine and serotonin pathways