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They can increase energy and improve quality of life for those with a deficiency, though individuals with normal B12 levels will not experience additional benefits from injections.

The one patient who received CMC-based artificial saliva only did not show symptom improvement

Self-administration without clinical oversight removes the safety layer that makes the protocol viable

Mild reactions, which include soreness at the injection site, a slight fever, or reduced appetite, may be seen but will resolve in one or two days

This may be related to the fact that AGEs can age and oxygenize the collagen and modify the collagen surface, which is known to affect cell-matrix interactions in a manner leading to exacerbated inflammation and may inhibit tendon repair [45, 46]