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Sen Li, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Skeletal Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Occasional reports of acquired 5-oxoprolinemia and 5-oxoprolinuria have attributed the disorder to the administration of several drugs other than acetaminophen

High levels of superoxide may react with NO and generate peroxynitrite, which is a harmful free radical [136]

Science 369 , eaay5356 (2020)