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Based on current clinical evidence, the rough ordering from largest to smallest weight-loss effect is: Tirzepatide highest average weight loss Semaglutide significant weight loss Tesamorelin moderate weight loss, primarily through visceral fat reduction AOD-9604 primarily body composition effects MOTS-c primarily metabolic and energy effects rather than pure weight reduction AOD-9604 and MOTS-c are generally not considered replacements for GLP-1 medications in patients seeking substantial weight reduction

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It is still not clear which signaling pathways NNMT is involved in for regulating autophagy

For cohort 1, the Ontario Drug Benefit (ODB) database was used to identify patients who were prescribed vitamin B12 injections