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The authors noted that short-term berberine treatment was well tolerated and exhibited a good safety profile

doi: 10.1126/science.1260419 21 ArunaPSowjanyaBReddyPAKrishnammaMNaiduJN

The failure of broader or less specific agents, therefore, reinforces the central theme that therapeutic success in MIRI demands a highly targeted approach that addresses the specific downstream consequences of the initial oxidative insult

Int J Vitam Nutr Res (2019) 89:808
The catecholamines are dopamine , norepinephrine , and epinephrine
