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RSL3-treated Treg cells accumulated lipid peroxides and died through a resultant ferroptosis, suggesting that Gpx4 is integral to maintaining Treg cell homeostasis

Specifically, the peptide downregulates inflammatory genes including interleukin-1, tumor necrosis factor-, and nuclear factor-B, while upregulating protective genes such as those encoding antioxidant enzymes, DNA repair proteins, and extracellular matrix components

J., Verhaegh, G

Evidence suggests that the mitochondrial GSH pool plays a critical role for cell survival [48]

The significant increase in serum ALT, AST, and ALP levels observed in rats exposed to high altitudes indicates hypoxia-induced mild hepatocellular leakage and loss of membrane integrity