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10.1096/fj.12-222745 55 NilssonL

Moreover, pretreatment with gemcitabine, a DNA-damaging agent, significantly enhances the cytotoxicity of BRAF inhibitors against resistant melanoma, pancreatic cancer and non-small cell lung cancer cells (130)

IGFBP Evasion and Enhanced Receptor Availability The biological potency of des-(1-3)-IGF-1 correlates inversely with its binding to proteins released into the medium by cells, so that its enhanced potency is a consequence of it not binding to purified binding proteins or those released by cultured cells

These pilot trials showed promising results in individuals with metastatic kidney cancer (21), metastatic colorectal cancer (22), and breast cancer with high risk of relapse (23)

The prooxidant activity of GGT has also recently been shown to promote the iron-dependent oxidative damage of DNA in GGT-transfected melanoma cells, thus potentially contributing to genomic instability and an increased mutation risk in cancer cells [50]