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(1965) Cleavage of S-(1,2-dichlorovinyl)-L-cysteine by an enzyme of bovine origin

Proc Natl Acad Sci USA 111: 28122817, 2014

identified ten genes through whole genome knockout screening that may modify susceptibility to cuproptosis, classifying FDX1, LIAS, LIPT1, DLD, DLAT, PDHA1and PDHB as positive regulators, and MTF1, GLS and CDKN2A as negative regulators

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More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27