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76 , e179e187 (2023)

Scientists have found good ways to block CD38: Apigenin, a natural flavonoid, stops CD38 from working and increases NAD+ inside cells Thiazoloquin(az)olin(on)e (78c) blocks CD38 so well it doubles NAD+ in normal cells but doesn't affect cells without CD38 NAMPT activation to improve NAD+ recycling NAMPT controls the key step in NAD+ recycling by turning nicotinamide into NMN

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Compr Physiol 5: 611647, 2015

For the majority of people, 8mg will be the sweet spot where results are excellent and the protocol feels sustainable long term