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Fawaz et al [32] investigated the in vitro effect of 1,25(OH) 2 D 3 and 25(OH)D 3 on the differentiation and cytokine production of primary CD4 + T cells from normal donors

The peptide also reduces inflammatory infiltration that can impair healing while improving vascular supply to damaged muscle tissue

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Metformin should be considered early in women with obesity and lipedema Stages II and III where fibrosis in the fat tissue is prominent, as well as in women who have signs of metabolic syndrome (69)

Conversely, caloric moderation within a balanced diet is essential, as excessive intake of fats or carbohydrates can impair mitochondrial function by promoting oxidative stress and metabolic imbalance [373]