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This correlation between FASN activity and LD formation is likely important in supporting energy homeostasis and promoting tumour cell survival, especially under metabolic stress [119]

372,373 In neoadjuvant endocrine therapy of HR+/HER2 breast cancer, achieving pCR is not the primary goal, therefore studies such as NeoMONARCH and PALLET focus on changes in Ki67 levels and complete cell cycle arrest with the addition of CDK4/6 inhibitors

In addition, glycogen autophagy is associated with a higher risk of heart disease (including DCM) in female patients, possibly because glycogen autophagy is associated with selective glycogen accumulation in the female myocardium, in which estrogen may upregulate the expression of signaling intermediates that promote glycogen storage (77) ( Figure 3 )

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