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For example, patients lacking the efficient capability of eliminating excessive Hcy might not be advised to use SAMe as a long-term treatment, and if they choose to use it, they should do so under physician supervision

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The b12 injection benefits for females tend to be particularly pronounced because women are statistically more likely to present with B12 insufficiency, especially those who are pregnant, postpartum, perimenopausal, or following a plant-based diet