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IGF-1 promotes cardiac development and improves cardiac output, stroke volume, contractility, and ejection fraction

Furthermore, the transcription factor NFE2 like bZIP transcription factor 2 (NFE2L2, best known as NRF2) is a pivotal regulator of the antioxidant system and controls the expression of genes central to antioxidant defense mechanisms [28]

Mechanistically, by constructing cardiomyocyte-specific conditional retinol dehydrogenase 10-knockout male mice and overexpressing retinol dehydrogenase 10 in male type 2 diabetic mice via adeno-associated virus, we verify that the reduction in cardiac retinol dehydrogenase 10 is the initiating factor for cardiac retinol metabolism disorder and results in diabetic cardiomyopathy through lipotoxicity and ferroptosis