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Replication, detoxification, and a cancer-protective form of regulated cell death termed ferroptosis , all depend on iron metabolism

J Clin Endocrinol Metab 76 : 309317 Kim KR et al

Overall, authors concluded that due to respiratory defects caused by SURF1 mutations, SURF1 NPCs retained glycolytic and proliferative features, which in turn hampered the establishment of neuronal morphogenesis

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However, it is well known that mitochondrial and cytosolic GSH levels are decoupled during cell death and many other biological processes 40